Chelsea won the FA Cup last season.
Manchester United will face rivals Manchester City in the semi-finals of the FA Cup if they can beat Chelsea in a sixth-round replay.
Sir Alex Ferguson's team, 4.00 to win the FA Cup, face a tricky trip to Stamford Bridge after throwing away a two-goal lead against Chelsea.
Indeed Chelsea, 2-0 down after only 11 minutes, almost won the match in the closing stages after goals by Eden Hazard and Ramires had brought them level.
Manchester City, 2.37 to win the FA Cup, had a far easier quarter-final encounter, thrashing Barnsley 5-0 on Saturday.
The draw means that a 'smaller' team will be definitely be in the FA Cup final in May after Wigan Athletic were paired with Millwall or Blackburn Rovers.
The Latics, 1.72 to be relegated this season, secured a shock 3-0 win at Everton on Saturday, while Championship duo Millwall and Blackburn played out a goalless draw on Sunday and face a replay at Ewood Park later this month.
FA Cup semi-final draw:
Millwall or Blackburn Rovers v Wigan Athletic
Manchester United or Chelsea v Manchester City