Tuilagi joins Corbisiero on sidelines
It is hoped Manu Tuilagi will have recovered in time for the Ireland match.
England will be without centre Manu Tuilagi and prop Alex Corbisiero for this weekend's Six Nations opener against Scotland.
Tuilagi has an ankle injury but is only expected to miss one match and could return for next month's clash against Ireland while Corbisiero will miss the whole championship with a knee injury.
Coach Stuart Lancaster confirmed: "Manu has run out of time for Scotland and we'll make a call on him for Ireland early next week."
Tuilagi played a key role in England's thrilling 38-21 victory against New Zealand almost two months ago when he scored one try and set up another.
However, the Leicester centre was withdrawn at the last minute from his club side when they faced Toulouse recently.
Corbisiero had an operation last week to clear out a "loose body" in his knee, an issue that has troubled him since England's summer tour of South Africa.
Manu has run out of time for Scotland and we'll make a call on him for Ireland early next week.Stuart Lancaster
It had been hoped that he would only miss the first two games of the Six Nations but now he will miss the entire tournament. England have called up the Sale Sharks prop Henry Thomas as a replacement.
Meanwhile, the Harlequins winger Ugo Monye has been drafted into the training squad as cover for Freddie Burns, who remains with Gloucester for treatment on a knee problem. England have also lost Tom Johnson for the entire tournament.
However, Leicester flanker Tom Croft has been passed fit to report for England duty, having sustained a back problem during his side's 34-8 LV= Cup win over Saracens at the weekend.
England are 1.071 to make a winning start in the Six Nations by seeing off Scotland and are 8.00 to win by 1-5 points, with the home side 2.50 to open the scoring with a penalty.
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